In most cases: no, ToolE is designed for standard one-to-one mapping.
What ToolE supports (recommended)
Standard parent/child structure (variants):
One Shopify product can have multiple variants, and each variant has its own SKU. ToolE links each Shopify variant → one Amazon SKU (one-to-one).This is the “standard” setup ToolE is built for, and linking works normally in this scenario.
What ToolE does not support (not recommended)
One Shopify variant linking to multiple Amazon SKUs
One Amazon SKU linking to multiple Shopify variants
Any one-to-many mapping or complex size-driven selection logic for multi-variant ASINs
If you need multiple SKUs
Create them as variants in Shopify (each with a unique SKU), so each one can map cleanly to the matching Amazon SKU.